buprenorphine transdermal and diazepam both equally enhance sedation. Stay clear of or Use Alternate Drug. Limit use to clients for whom alternative remedy possibilities are inadequate
Adjunct use, if apprehension, stress and anxiety or acute pressure reactions existing previous to endoscopic processes
enzalutamide will lower the extent or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
drospirenone will increase the stage or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.
You happen to be alarmed by how frequently the seizures happen, by how serious the seizure is, by how long the seizure lasts, or by the color or breathing of the person.
Retain VALTOCO in a secure area to circumvent misuse and abuse. Advertising or giving away VALTOCO may possibly hurt Some others and it is towards the regulation. Convey to your healthcare provider For those who have abused or been dependent on Alcoholic beverages, prescription check here medications, or Road drugs. It is not acknowledged if VALTOCO is Secure and successful in small children under six many years of age. Essential Security Data
Antegrade amnesia may possibly come about working with therapeutic dosages, the risk increasing at higher dosages; amnestic consequences might be linked to inappropriate conduct
diazepam will increase the degree or influence of midazolam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Coadministration of moderate CYP3A4 inhibitors with midazolam intranasal may perhaps cause greater midazolam systemic exposure, which can extend sedation.
Watch Closely (1)triclabendazole will boost the level or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism.
Lonafarnib may well increase the AUC and peak concentration of CYP2C19 substrates. If coadministration unavoidable, keep an eye on for adverse reactions and decrease the CYP2C19 substrate dose in accordance with its authorised item labeling.
Reserve concomitant prescribing of these medications in sufferers for whom other remedy options are inadequate. Limit dosages and durations to the least expected. Check intently for indications of respiratory despair and sedation.
Oral: Info not out there No dose adjustment suggested Except if administered for prolonged time period; lessen dose in prolonged periods
Titrate IV dosage to wanted sedative reaction, for example slurring of speech, with gradual administration immediately before process
cyclosporine will raise the stage or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.